• br Introduction Alzheimer s disease AD

  2022-06-15

  

  Introduction Alzheimer's disease (AD) affects ca. 46 million people worldwide [1] and it is expected that the number will double or triple by 2030 or 2050, respectively, while no significant progress has been made in research for early diagnosis and new efficient therapies. Currently available me

• As shown in Table the results of individual

  2022-06-15

  

  As shown in Table 3, the results of individual prediction modeling with chemicals at 0.4 mM, 0.6 mM, and 0.8 mM would lead to lesser sensitivity of 60.0%, 65.0%, and 65.0%, respectively, in microsome-unused group, and 85.0%, 85.0%, and 90.0%, in microsome-used group. If we consider only the results

• The optimum parameter sets were

  2022-06-15

  

  The optimum parameter sets were detected by the highest J-statistic for the training set and applied to the test set for evaluation. J-statistics obtained from the test set is reported at Table 2 along with respective parameters. We also applied QP, G4H and PQSF methods, in order to compare the pre

• Clinical data showed TAK was

  2022-06-15

  

  Clinical data showed TAK-875 was rapidly absorbed with a half-life of 28-30h and clearance primarily through glucouronidation in the liver with minimal urinary clearance [30]. TAK-875 made the glycosylated hemoglobin (HbA1c) levels fall significantly from baseline after 24-week administration in onc

• Studies of human and mouse GPR as ascertained by

  2022-06-15

  

  Studies of human and mouse GPR84, as ascertained by mRNA levels in various tissues, have determined that GPR84 is highly expressed on bone marrow cells, splenic T and B cells, and circulating granulocytes/monocytes/macrophages. In the latter cells, mRNA expression of is up-regulated only under infl

• Our previous study had shown that silencing FFAR expression

  2022-06-15

  

  Our previous study had shown that silencing FFAR1 expression weakened the action of PIO in increasing insulin secretion in lipotoxic β SKF 83566 hydrobromide receptor [6]. Resent research found that PIO promoted insulin secretion by upregulating FFAR1 [17]. Therefore, we presumed that FFAR1 may be i

• br Materials and methods br Results and discussion br Conclu

  2022-06-15

  

  Materials and methods Results and discussion Conclusion The as-designed system was based on the assembly of MSN-Cy and TPGS, which was dominated by π-π stacking interactions. By the strong mutual force, Cypate and TPGS formed a compact layer around the MSN core, which blocked the drug leaka

• The root of Danshen has been widely used

  2022-06-15

  

  The root of (Danshen) has been widely used as traditional Chinese medicine for many years and shown to exhibit significant pharmacological activities for a variety of human diseases including cancers. Tanshinones, the major active components, belong to a group of an abietane-type diterpenes contain

• The central region of Azalanstat can be substituted with con

  2022-06-15

  

  The central region of Azalanstat can be substituted with connecting alkyl chains of different nature and length. Interesting results were given by compounds with a four or five ATI-2341 chain, incorporating heteroatoms, such as oxygen (Fig. 2, compound 4) or sulfur, and different functional groups s

• It was speculated that could affect

  2022-06-15

  

  It was speculated that could affect the protein translation or processing in the HCV replication cycle. The viral protein processing was thus investigated, to establish whether the HCV inhibition was determining an increased amount of unprocessed polyprotein, due to a block in the processing, or a r

• br Introduction Herpes viruses are members

  2022-06-14

  

  Introduction Herpes viruses are members of Herpesviridae family. This family consists of DNA viruses and it is a very large family. The viruses related to this family cause many diseases in animals and humans [1]. Herpes simplex viruses cause mucocutaneous lesions in the affected humans. These le

• Kern et al observed an overall improvement in behaviors typi

  2022-06-14

  

  Kern et al observed an overall improvement in behaviors typical for autism during TR. They used the Childhood Autism Rating Score (CARS), to determine the intensity of the change and found lower CARS values after 3 (t(21) = 2.73, p ipi-145 comparison of differences in QoL improvement in both groups,

• br Materials and methods br Results br Conclusions

  2022-06-14

  

  Materials and methods Results Conclusions We developed a glutamate biosensor with chitosan as a matrix for the immobilization of the enzyme glutamate oxidase on the surface of a platinum electrode. Our miniaturized biosensor of 50 µm in diameter can be applied for monitoring glutamate in vi

• Natural products have been always the most important

  2022-06-14

  

  Natural products have been always the most important and productive sources of lead compounds for the development of drugs [[15], [16], [17]]. A variety of potent α-glucosidase inhibitors have been identified from natural products, such as quercetin, resveratrol, isorhamnetin, calein C and curcumin

• In accordance with its similarity to classical NLSs

  2022-06-14

  

  In accordance with its similarity to classical NLSs, Importin α3 was recently reported as a nuclear transport receptor for Ci (). We therefore superimposed the Gli1 NLS model with the Importin α2 structure (3EFX), which has a structure similar to Drosophila Importin α3 () (Fig. 4.4B). Gli1 NLS fitte

13990 records 358/933 page Previous Next First page 上5页 356357358359360 下5页 Last page