• Studies of early cell fate specification in

  2022-10-02

  

  Studies of early cell fate specification in the mouse embryo have identified a role for differential Motin localization in controlling Hippo signaling [88]. At the 32-cell stage, mouse blastomeres are subdivided into inner cells, which form the inner cell mass (ICM), and outer cells, which form the

• br Brief overview of GSK inhibitors We

  2022-10-01

  

  Brief overview of GSK-3 inhibitors We will briefly summarize some of the key aspects about GSK-3 inhibitors. Additional details of GSK-3 inhibitors in clinical trials have been recently reviewed [5]. GSK-3 is a complicated target as it is involved in many biological processes from neurology, diab

• The expression of heat shock proteins HSPs can

  2022-10-01

  

  The expression of heat-shock proteins (HSPs) can be upregulated by viral infection, nutritional deficiency, TNF-α and oxidative stress in INDY australia [44], [45] HSPs are classified in six families (including the HSP10, HSP40, HSP60, HSP70, HSP90 and HSP100 families). HSP90 [46] for example provid

• The average pregnancy rate in this work

  2022-10-01

  

  The average pregnancy rate in this work was 60.1%; similar results have been reported with the same estrus synchronization treatment (58% pregnancy rate) [26]. Later studies also showed that the pregnancy rate was 56.9 and 51.1%, with FTAI and estrous detection, respectively [34,35]. Although that t

• Although both receptors mGluR and

  2022-09-30

  

  Although both receptors, mGluR1 and mGluR5, are present in cortical and hippocampal areas from 1 to 2 weeks old neonates (López-Bendito et al., 2002) we have found that only mGluR1 was regulated after maternal l-Glu consumption. A possible explanation could be based on the different ontogenetic prof

• In addition this study also showed no obvious increase in

  2022-09-30

  

  In addition, this study also showed no obvious increase in apoptosis but obvious increase in necrosis after WZB117 treatment. The possible reason is that apoptosis is an ATP-utilizing process which is an active and programmed form of cell death. In contrast, necrosis is an uncontrolled or pathologic

• br Acknowledgments br Introduction Postmenopausal

  2022-09-30

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by Kinase Inhibitor Library deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approxi

• br Acknowledgments This work was supported by the NIH

  2022-09-30

  

  Acknowledgments This work was supported by the NIH (R01DK103884 to JMZ, R01DK100659 to JKE, and F32DK104659 and K01DK111644 to CMC), the Diana and Richard C. Strauss Professorship in Biomedical Research, the Mr. and Mrs. Bruce G. Brookshire Professorship in Medicine, the Kent and Jodi Foster Dist

• Cx is the major molecule involved in the

  2022-09-30

  

  Cx43 is the major molecule involved in the dynamic life cycle of GJIC (Cusato et al., 2006). Initially generated Cx43 exist in the cytoplasm and correctly transfer it to the plasma membrane during its life cycle (Ji et al., 2018). To understand the toxic effects of MC-LR on GJIC, Cx43 localization w

• DNAzymes a series of nucleotide sequences with

  2022-09-30

  

  DNAzymes, a series of nucleotide sequences with specific catalytic activity, have been reported frequently applied in detection assays for such as ions and amino acids, due to the advantage in stability, high cost-effectiveness and modification convenience, by comparison with protein enzymes. The DN

• LXRs are physiological regulators of cholesterol and lipid m

  2022-09-30

  

  LXRs are physiological regulators of cholesterol and lipid metabolism and influence glucose metabolism. In addition, they have been shown to repress transcription of certain pro-inflammatory genes (Jakobsson et al., 2012; Ogawa et al., 2005; Terasaka et al., 2005). Thus, LXRs can either activate or

• Whether ferroptosis specific inhibitor could promotes spinal

  2022-09-30

  

  Whether ferroptosis specific inhibitor could promotes spinal cord repair is a question worth to explore. A potent and stable ferroptosis specific inhibitor is essential for in vivo study. Ferrostatin-1 (Fer-1), the first generation of ferroptosis inhibitor, was shown actively suppressing ferroptosis

• br Materials and methods br Results br Discussion EZH

  2022-09-29

  

  Materials and methods Results Discussion EZH2 is a subunit of the polycomb repressive complex, which trimethylates lysine 27 on histone 3, a repressive marker for gene expression. EZH2 is important for cancer cell proliferation, migration, and invasion, all of which are associated with canc

• In addition the interplay of

  2022-09-29

  

  In addition the interplay of membrane curvature induced tension at the fusion pore and ion channel induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity warrant further r

• We found statistically significant association between p

  2022-09-29

  

  We found statistically significant association between p95-HER2 levels and hormone receptor status, Ki-67 3-Chlorotyrosine and metastatic regions (p = 0.004,  0.05) and the median OS was 27.66 months versus 24.02 months for p95-HER2 positive and p95-HER2 negative BC patients respectively (p > 0.05)

14621 records 351/975 page Previous Next First page 上5页 351352353354355 下5页 Last page