• 5α-dihydro-11-keto Testosterone The clinical impact of our f

  2023-02-01

  

  The clinical impact of our findings is also supported by our earlier report that the level of 12-LOX expression was correlated with the tumor stage and grade [17], [52] and that overall, 38% of patients demonstrated elevated levels of 12-LOX in prostate cancer tissue compared with their matching nor

• Caffeic acid dihydroxycinnamic acid is a

  2023-02-01

  

  Caffeic HATU receptor (3,4-dihydroxycinnamic acid) is a natural compound that inhibits 5-LO and exerts potent anti-inflammatory and antioxidant properties. Recently, Takeda et al. reported that caffeic acid provided neuroprotective and anti-depressive activities [23]. Sertraline, a selective seroto

• br Discussion Here we focused on seven

  2023-02-01

  

  Discussion Here, we focused on seven plant alkaloids extracted from yokukansan. These alkaloids individually inhibited 5-HT-mediated 5-HT3A and 5-HT3AB receptor currents weakly. Simultaneous administration of these alkaloids, however, inhibited the 5-HT3A and 5-HT3AB receptor currents strongly. T

• Enhanced arginase activity and the resultant decreases

  2023-01-31

  

  Enhanced arginase activity and the resultant decreases in L-arginine levels can also impair T cell mediated immune function and allow tumor growth by limiting the supply of L-arginine needed for the formation of cytotoxic levels of NO by iNOS [10]. Increased arginase expression/activity may also lim

• Introduction Alzheimer s disease AD is

  2023-01-31

  

  Introduction Alzheimer's disease (AD) is a complex neurological disorder characterized by a progressive dementia resulting from synapse failure (Selkoe, 2002, Tanzi, 2005). The amyloid hypothesis maintains that the pivotal event in AD is the production of amyloid-β (Aβ) peptides following the prot

• In conclusion we show that HBP

  2023-01-31

  

  In conclusion, we show that HBP1 is phosphorylated on three sites, which control HBP1 transcriptional activity and glioblastoma cell proliferation. This phosphorylation largely depends on AKT, although other kinases may also be involved. In a previous study, we had shown that the PI3K-AKT pathway re

• The functional observations from the present study are

  2023-01-31

  

  The functional observations from the present study are based on neoplastic fak pathway (HSY), and comparative expressions between normal salivary and pleomorphic adenoma tissues. However, there is a paucity of information on AhR expression and function in normal salivary gland, not neoplastic, cells

• annexin v The enzyme plays an important role

  2023-01-31

  

  The enzyme plays an important role in the purine metabolism of this parasite. Like other parasitic protozoa, T. gondii is incapable of de novo purine biosynthesis and depends totally on preformed purines salvaged from the host annexin v for its purine requirements and survival (Perrotto et al., 1971

• In this study we obtained the absorbance and

  2023-01-31

  

  In this study, we obtained the absorbance and photoluminescence (PL) of Cyclic Pifithrin-α hydrobromide polymerized with various types of actin-binding proteins in order to probe the actin structures in situ without labeling. Both optical measurements have been useful in examining biomaterials such

• As described in the introductory

  2023-01-31

  

  As described in the introductory section, the rotifer nervous system would be capable to transmit 4-HQN in throughout its neural pathways. In addition, Clément and Amsellem (1989) and Kotikova et al. (2001) suggested acetylcholine to be important for the functioning of rotifer muscles and their con

• A role for YAP in mediating resistance

  2023-01-31

  

  A role for YAP in mediating resistance to EGFR inhibition has also been described [28], [29]. In line with these evidences, we observed increased YAP activation in all the generated EGFR TKI–resistant cells, testified by decreased phosphorylation on the inhibitory serine 127, enhanced nuclear locali

• Autotaxin has been linked to chemoresistance through its abi

  2023-01-31

  

  Autotaxin has been linked to chemoresistance through its ability to inhibit apoptosis induced by paclitaxel in breast cancer azd synthesis [15] and LPA can inhibit cell death induced by cisplatin [40]. Autotaxin was included in the present study because it was identified as being over-expressed in p

• Introduction the DNA damage response

  2023-01-31

  

  Introduction: the DNA damage response — important implications for tumour development and treatment Cells are invariably challenged by tens of thousands of lesions inflicted on their DNA everyday (Lindhal, 1993). This DNA damage can be caused exogenously by exposure to different types of radiation

• Previous studies demonstrate that chiral

  2023-01-30

  

  Previous studies demonstrate that chiral biointerface has great influence on cells adhesion and proteins adsorption [39], [40], [41], [42], [43], which inspired us to further develop antimicrobial materials or surfaces by taking advantage of the “chiral taste” of microbes. L-borneol is a hydrophobi

• Forsythoside A That increased longevity was not

  2023-01-30

  

  That increased longevity was not the exclusive result of blood pressure reduction. This was demonstrated by analysis of life-long, whole body deletion of AT1A receptors in normotensive mice. These animals exhibited a very significant increase in lifespan when compared to wild- type mice [159], [160]

14621 records 320/975 page Previous Next First page 上5页 316317318319320 下5页 Last page