• Another important question concerns the mechanism by which a

  2024-07-05

  

  Another important question concerns the mechanism by which a polyubiquitinated substrate is released from the Cdc48 complex and passed on to downstream components, such as the proteasome. There are at least three proposed models. In the first, a ubiquitinated substrate is transferred by ubiquitin-bi

• br Conclusion We have identified potential inhibitors of C

  2024-07-05

  

  Conclusion We have identified potential inhibitors of C. albicans fungus specific nuclear target outer kinetochore Dam1 complex subunit Ask1, virtually screened through the PubChem compounds database (NCBI, USA) by utilizing state-of-art in silico methods in a pipeline. The 3D protein structure o

• As a neuropeptide Apelin also has a critical role

  2024-07-05

  

  As a neuropeptide, Apelin also has a critical role in cardiovascular diseases. Systemic administration of Apelin exert vasodilatory and antihypertensive effects [33]. Meanwhile, the apelin-APJ signal transduction pathway is related to age-associated cardiovascular diseases [34]. It has been known th

• Overall we found maternal antibiotics to be

  2024-07-04

  

  Overall, we found maternal CC-223 to be associated with improved outcomes. In these multiple logistic regression models, high postnatal empiric infant antibiotic exposure was not significantly associated with risk for NEC or LOS. However, consistent with previous studies,5, 6 receipt of high empiric

• The central problem in amnesia developing following impairme

  2024-07-04

  

  The central problem in amnesia developing following impairment of long-term memory consolidation or reconsolidation is a question of the underlying mechanisms, whether it is caused by impairment of retrieval or memory storage mechanisms [3,8,9,[15], [16], [17], [18]]. To answer this question, severa

• br Materials and methods br Results Bilateral

  2024-07-04

  

  Materials and methods Results Bilateral microinjections (n = 6) of 10 mM ACh (300–500 pmol) and 5 mM physostigmine (150–250 pmol) at the two selected caudal NTS sites caused within 1 min significant increases in respiratory frequency (from 54.5 ± 1.7 to 70.9 ± 4.1 breaths/min; +30.8 ± 7.0%; P

• Inhibitors of mPGES are considered as safe alternative to

  2024-07-04

  

  Inhibitors of mPGES-1 are considered as safe alternative to NSAIDs in the treatment of chronic inflammatory diseases that are characterized by excessive PGE2 production (Bahia et al., 2014; Khurana and Jachak, 2016; Koeberle et al., 2016; Korotkova and Jakobsson, 2014; Norberg et al., 2013; Psarra e

• The amino hydroxy methyl isoxazolepropionic acid

  2024-07-03

  

  The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic DAMGO (AMPA) receptor is also enriched in postsynaptic striatal neurons (Bernard et al., 1997, Kondo et al., 2000, Reimers et al., 2011). Its activity is subjected to the regulation by a mechanism involving phosphorylation (Lu and Roche, 2012). For

• br APJ expression in metabolic diseases Under physiological

  2024-07-03

  

  APJ expression in metabolic diseases Under physiological conditions, APJ is present in humans as well as in mouse tissues with high metabolic activity such as muscle and adipose tissue but not in the liver. Moreover, the presence and regulation of APJ in established adipocyte or muscle cell lines

• The results of our in vivo experiments

  2024-07-03

  

  The results of our in vivo experiments provide promising evidence that the apelin/APLNR axis is implicated in CCA growth and that targeting this axis with a receptor specific antagonist may help develop effective, tumor directed therapies. Not only do we show decreased proliferation and angiogenesis

• Since E was shown to affect the expression of Hsps

  2024-07-03

  

  Since E2 was shown to affect the expression of Hsps, the transcript expression levels of another 11 Hsps were also evaluated by real-time PCR with their specific primers. The transcripts of 4 proteins (Hsp10, Hsp56, Hsp70a and Hsp110) were significantly up-regulated, but that of Hsp47 was significan

• Plant defensins Vriens et al and linear AMPs

  2024-07-03

  

  Plant defensins (Vriens et al., 2014) and linear AMPs (Domingues et al., 2015, Liu et al., 2008) have been shown to present several modes of action. Among these different mechanisms, permeabilization of the fungal membrane has been described as a secondary effect of plant defensin action (Vriens et 

• Introduction Cardiovascular disease is the principal

  2024-07-03

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with p0035 (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiovascular risk f

• Circular dichroism CD provides useful

  2024-07-03

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light sodium salt australia spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than

• Psora 4 australia br Perspectives br Acknowledgments This in

  2024-07-03

  

  Perspectives Acknowledgments This investigation was supported by a Research Grant 2010/01385-5 from FAPESP (Sao Paulo Research Foundation, Brazil). P.F.S. was recipient of a CNPq (National Council for Scientific and Technological Development, Brazil) productivity grant. R.F.A. was recipient of

14621 records 120/975 page Previous Next First page 上5页 116117118119120 下5页 Last page