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br Conclusion The results of the
2019-07-15
Conclusion The results of the present study demonstrate that cysteinyl leukotrienes LTC4, LTD4 and LTE4 cause moderate to marked whereas the dihydroxy leukotriene LTB4 causes small muscle contraction in the stomach in vitro. The LTD4-induced contraction is mediated by CysLT1 in fundus but by CysL
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Kim et al reported for bioactive compounds originating from
2019-07-15
Kim et al. reported for bioactive compounds originating from the endemic species in Korea, the hexane and EtOAc fractions of the MeOH extracts from the roots of Dystaenia takeshimana (Nakai) Kitagawa (Umbelliferae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity b
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Notably HSP expression is under control of the tetrameric
2019-07-15
Notably, HSP27 expression is under control of the tetrameric form of CK2 holoenzyme, as knockout or knockdown of the β regulatory subunit alone reproduces the same effects of targeting the α/α′ catalytic subunits. This observation discloses the possibility to use more specific drugs that affects onl
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The underlying mechanisms of how progesterone prolongs pregn
2019-07-15
The underlying mechanisms of how progesterone prolongs pregnancy, although not completely understood, are thought to have to do with reduction in uterine contractility, antimicrobial protein up-regulation, immunosuppression, and inflammatory inhibition. Specific to preterm PROM, progesterone has bee
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csf-1r In summary we have identified a series of amides
2019-07-15
In summary, we have identified a series of amides as ERRγ agonists with suitable potency for further development. Our SAR studies of this chemotype identified SR19881 as the most potent full agonist of ERRγ with an EC=0.39 μM in a binding assay and an EC=4.7 μM in a cell-based assay. SR19881 was als
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From an industrial perspective the low
2019-07-15
From an industrial perspective, the low turnover numbers and limited substrate scope of α-KG halogenases still represents a significant challenge. However, in light of the fact that currently no chemical processes are available for the selective halogenation of aliphatic carbon centers in complex mo
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Recently experimentally exposed common carp took up CLO from
2019-07-15
Recently, experimentally-exposed common carp took up CLO from water and maintained a consistent concentration in the liver and blood plasma (Corcoran et al., 2014). Clotrimazole may influence other aquatic organisms. Survival and development of marine shrimp larvae (Palaemon serratus) were affected
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br Materials and methods br Results br Discussion
2019-07-15
Materials and methods Results Discussion Plg plays important roles in various physiological processes, such as fibrinolysis, proteolysis, cell migration, differentiation, tissue remodeling, and inflammation [6], [7], [8]. We herein found that Plg deficiency enhanced insulin secretion, and w
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It is now well accepted that
2019-07-13
It is now well accepted that increased local estrogen levels are associated with both the onset and growth of breast cancer. Tissue concentrations of estradiol (E2) in breast cancer are 10 times higher than that found in plasma [12].
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Future direction and conclusion
2019-07-12
Introduction Colony stimulating factor-1 (CSF-1; also referred to as the macrophage-colony stimulating factor) is the primary regulator of proliferation, differentiation, and survival of macrophages and their precursors (Barreda et al., 2004). It also controls key aspects of macrophage function including microbicidal activity (O\'Mahony et al, 2008, Roilides et al, 1996), cytokine (Chitu, Stanley, 2006, Evans et al, 1995) and chemokine (Hashimoto et al, 1996, Sweet, Hume, 2003) production, chemotaxis (Boocock et al, 1989, Webb et al, 1996), and phagocytosis (Akagawa, 2002, Cheers et al, 1989).
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CDKs as Direct Coactivators of
2019-07-11
CDKs as Direct Coactivators of Proinflammatory Transcription Factors CDKs fuel inflammation by triggering the function of proinflammatory transcription factors such as NF-κB, STAT3, and AP-1. This is achieved at two levels because CDKs can affect gene expression by targeting global transcription by phosphorylation of the RNA Pol II CTD and also in a highly specific manner upon direct association and regulation of proinflammatory transcription factors, as summarized in Figure 2A.
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To further investigate mechanisms
2019-07-10
To further investigate mechanisms of rXCI, we generated female ESCs with a homozygous RlimKO. We found that these Ro 04-5595 undergo XCI in vivo but that XCI in vitro is strongly influenced by culture conditions, including both method of differentiation and O2 levels. Our results demonstrate Rlim-dependent and Rlim-independent pathways for XCI exist in ESCs and, together with published data, profoundly change current models of X dosage compensation.
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Discussion Although some conditioning therapies
2019-07-09
Discussion Although some conditioning therapies have provided satisfactory clinical outcomes, mammalian species have little or no ability to replace injured cardiac tissue [34]. Therefore, therapeutic strategies based on the prevention, rather than treatment after the heart has already been damaged, emerge as promising strategies. In this context, the main findings of this study are as follows
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Building applications by selecting and
2019-07-08
Building applications by selecting and integrating components is known in software engineering as COTS-based development. Nowadays, this approach is recognized as a crucial success factor for the software industry (Ahuja, 2014). The advantages of using COTS components include minimizing the overall development and maintenance costs of software. The use of COTS products is also associated with reducing risks of software development and shortening time-to-market for software application being developed. As evidence, Vale et al.
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Our ex vivo analysis demonstrates
2019-07-05
Our ex vivo analysis demonstrates that IL-15 promotes CD122 expression in DGKζ-deficient CD8+ T cells. CD122, which forms a dimer with CD132 in response to IL-2 or IL-15, activates the JAK/STAT and PI3K/mTOR pathways. Whereas antigen-stimulated Caspase-3 promote IL-2 sensitivity through up-regulation of the IL-2Rα chain, IL-15 potentiates self-responsiveness through a positive feedback loop that involves PDK1/mTOR/E4BP4/CD122 signaling (Yang et al., 2015).
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