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Steady state mRNA levels of CYP A isoforms
2019-09-09
Steady-state mRNA levels of CYP3A isoforms were not changed during liver insufficiency. Suppression of these isoforms was observed only at the protein and activity levels, suggesting a nongenomic mechanism of CYP3A isoform downregulation during liver insufficiency. Nonetheless, transcriptional activ
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The upregulation of PTGS and PTGS
2019-09-09
The upregulation of PTGS1 and PTGS2 in late gestation in mares could be linked to the high levels of estrogens produced by the fetoplacental unit. Estrogens are thought to be effective stimulators of prostaglandin production by potentially up regulating PTGS2 expression. Although a recent publicatio
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In the current study although
2019-09-07
In the current study, although EP4 agonist was the most effective in relaxing corpus cavernosum, it did not affect the neuronally-mediated relaxation. On the other hand, both alprostadil and iloprost, which were less effective as direct relaxants, potentiated EFS-induced relaxation of rat corpus cav
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However the Moon is not
2019-09-07
However, the Moon is not the only possible source for space resources. Asteroids, in particular near-Earth asteroids (NEAs), can provide an alternative source for propellant and other materials, sometimes at lower cost. There are an expected 4000 NEAs that require less propellant (delta-V) per trip
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br Acknowledgment br Introduction Pesticides are
2019-09-07
Acknowledgment Introduction Pesticides are largely used in agriculture to enhance food production and, to a lesser extent, to control unwanted pests and disease vectors in public health. However, these compounds are often associated with toxicity in non-target species including humans. Occupat
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br Acknowledgments This research was financially
2019-09-07
Acknowledgments This research was financially supported by National Natural Science Foundation of China, Nos. 31500926 and 81503282, Natural Science Fund of Guangdong Province, No 2014A030310023, Science and Technology Plan of Guangdong Province, Nos. 2014A020212309, 2013B010404044, 2017A01010501
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The objective of the present work is to search for
2019-09-07
The objective of the present work is to search for the optimum blend when 12.5–50% metakaolin is substituted by RHA and reacted with 10 M sodium hydroxide solution to produce geopolymers. It was hypothesized that the amorphous bosentan from RHA will increase the Si/Al ratio of the mix and in situ r
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So far several important flovonoids and polyphenoilc compoun
2019-09-07
So far, several important flovonoids and polyphenoilc compounds were subjected to various human studies regarding their potential therapeutic and adverse effects (Ide et al., 2014; Turner et al., 2015; Witte et al., 2014) (Table 1). Resveratrol (trans-3,4, 5-trihydroxystilbene) is widespread stilbe
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Zalcitabine pathway It is well known that acrolein
2019-09-07
It is well known that acrolein, a metabolite of cyclophosphamide, is responsible for the cyclophosphamide-induced cystitis, and that acrolein is capable of activating TRPA1 channels expressed in the capsaicin-sensitive primary afferents [2], [11]. In this context, it is likely that the early phase o
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br Results br Discussion In this paper we present insights
2019-09-07
Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 hoechst 33342 via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selective Ub-E1 i
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br Conclusions We can conclude that Arg
2019-09-07
Conclusions We can conclude that Arg293 is important but not indispensable for MeGlcA recognition by EcXyn30A since the R293A variant still retains activity and preference for MeGlcA-substituted substrates. The substrate specificity of GH30_8 glucuronoxylanases is most probably determined by an o
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The quaternary structure of many of the
2019-09-07
The quaternary structure of many of the family B members (i.e., secretin, glucagon, glucagon-like peptide and abiraterone acetate receptors) have been actively studied and it has been demonstrated that they can form homodimers/oligomers (Gao et al., 2009; Ng & Chow, 2015; Ng, Lee, & Chow, 2013). Har
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Interestingly all three lesions that significantly inhibited
2019-09-07
Interestingly, all three lesions that significantly inhibited transcription – CPD, εA and the AP site, – promoted insertion of desogestrel residues opposite the damaged nucleotide. Thus, bacterial RNAP seems to follow the so-called ‘A-rule’ for incorporation of nucleotides opposite AP-sites and bul
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In most cases patients will not present immediately
2019-09-07
In most cases, patients will not present immediately after SM exposure because SM-induced clinical symptoms typically occur after a latency period of several hours [8], [9], [10]. When they do present, the detection of free, unbound alkylating agent is highly unlikely. For this reason, available rap
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Ten non FH ADH probands fulfilled the
2019-09-06
Ten non-FH ADH probands fulfilled the diagnostic criteria of hyperabsorbers. Table 2 shows the main lipid characteristics of these subjects and of 10 non-hyperabsorber probands used for comparison. There were differences between groups in body mass index, waist circumference and triglycerides. Other
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