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Materials and Methods br Results br
2019-11-08
Materials and Methods Results Discussion For several decades, the diagnosis of translocation-associated childhood sarcomas with overlapping morphological characteristics has been facilitated by pathognomonic gene fusion detection through RT-PCR or FISH. However, these assays have several shor
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br Materials and Methods br Results
2019-11-08
Materials and Methods Results Discussion The spatial properties of receptor-ligand interactions can influence receptor activation and signal propagation, but studying this phenomenon requires the development of systems capable of recapitulating complex biophysical traits. In this study, we
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We obtained two bands in RT PCR for detection
2019-11-07
We obtained two bands in RT-PCR for detection of SERPIN1-FOSB fusion when Taq DNA polymerase was used (Fig. 3A). Genuine RT-PCR product of SERPIN1-FOSB fusion was proved to be the shorter one (733 Paeonol pairs) by sequencing, and the longer band (863 base pairs) was shown to be derived from native
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In addition to PGC transcriptional co repressors such
2019-11-07
In addition to PGC1α, transcriptional co-repressors such as NCOR and RIP140 participate in oxidative muscle remodeling induced by exercise, whereby reductions in their expression and the resulting de-repression of downstream TFs activates oxidative gene expression (Seth et al., 2007, Yamamoto et al.
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br Conclusions br Declaration of
2019-11-07
Conclusions Declaration of interest Acknowledgment This work was supported by an AIRC (Associazione Italiana Ricerca Cancro-Milan) Grant KFR062-2 to A.G.L, by Ricerca Funds by Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico (Grant No. 180/01) and by the ERA-NET “ERare” (Grant GO
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br Declaration of conflicting interests br
2019-11-07
Declaration of conflicting interests Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by CT Stem Cell grant # 15-RMB-YALE-07 (to L.E.N), and by an unrestricted Research Gift from
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Our observation that nuclear but not cytoplasmic EP expressi
2019-11-07
Our observation that nuclear, but not cytoplasmic EP4 expression is associated with different outcomes is interesting. In breast cancer, using the same methods, we did not detect EP4 in the nucleus of malignant pituitary adenylate cyclase-activating peptide whereas cytoplasmic EP4 was commonly obse
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In normal cells the apoptotic stimuli lower the expression
2019-11-07
In normal cells, the apoptotic stimuli lower the expression level of antiapoptotic proteins by increasing turnover rate and preventing the constant degradation of proapoptotic proteins. Thus, the dysregulation of anti-/pro-apoptotic proteins will confer the survival of cancer teva 3026 via enhancin
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br Methods br Results br Discussion To our
2019-11-07
Methods Results Discussion To our knowledge, this is the first report to investigate the association between DBH genotype and pDβH activity in Han Chinese subjects. We also examined the relationship among DBH gene polymorphisms, pDβH activity and cognitive function in patients with schizoph
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The compounds listed in Table Table Table Table
2019-11-07
The compounds listed in Table 1, Table 2, Table 3, Table 4, Table 5 were biologically evaluated for their inhibition of the specific binding of a radiolabeled ligand [3H]PGE2 to membrane fractions prepared from cells stably expressing each mouse prostanoid receptor. The EP1 antagonist activity of th
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br Competing interests br Acknowledgements br Introduction D
2019-11-06
Competing interests Acknowledgements Introduction Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) in biomembranes to produce phosphatidic spleen tyrosine kinase (PA) [1], [2], [3], [4], [5], [6]. To date, ten mammalian DGK isozymes (α, β, γ, δ, ε, ζ, η, θ, ι and κ) have been
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br Results This study was
2019-11-06
Results This study was carried out with a series of engineered extracellular matrix films of collagen assembled at hydrophobic surfaces, which allow for independent control of supramolecular structure, mechanical stiffness, and receptor recognition sites [17], [21]. Vascular smooth muscle myosin
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We used two different VSMCs cell lines
2019-11-06
We used two different VSMCs cell lines, KSB and CSD (isolated from two different thoracic aortas). Rat aortic VSMCs were isolated from medial segments from thoracic rate Benzoylhypaconitine from Wistar-Kyoto rats (six to eight weeks old, Charles River Wiga GmbH) and cultured over several passages a
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br Materials and methods br Results and discussion br
2019-11-06
Materials and methods Results and discussion Conclusions Codon-optimized MGSK-Lys-C was expressed at a high level in an optimized expression system as inclusion bodies. The Lys-C activity reached its maximum with about 9340 nkat/Lculture under standard (chemical) refolding conditions. The r
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Methacholine MCh is a bronchoconstrictive agent that has bee
2019-11-06
Methacholine (MCh) is a bronchoconstrictive agent that has been widely used in the diagnoses of airway narrowing and hyperresponsiveness (Jonasson et al., 2009). MCh induces muscle contractions by stimulating the muscarinic cholinergic receptors that are found in both the airways and the lung parenc
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