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In our xenograft study Fig
2020-07-11
In our xenograft study (Fig. 7, Fig. 8), we observed that DYD acts very similarly to progesterone; the initial faster tumor growth in the PGRMC1-transfected MCF7 tumor was not significant compared with that with progesterone, in prostaglandin receptor to the greater tumor growth observed with noreth
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br Criteria for ER targeted fluorescent probes br Survey
2020-07-11
Criteria for ER-targeted fluorescent probes Survey of fluorescent probes Proposed approach to high affinity fluorescent steroidal ER probes Our proposed approach to the development of a new generation of fluorescent estrogen receptor imaging agents employs many of the elements present in th
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Next we compared the protease specificity of
2020-07-11
Next, we compared the protease-specificity of viruses NS116-GFP/AE and NS116-GFP/AT for trypsin, neutrophilic elastase or supernatant of human neutrophils. For later purposes, we determined the viral yield in a co-cultivation system of infected Vero pfk with human neutrophils. The NS116-GFP/elastas
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br RING type E s and their
2020-07-11
RING-type E3s and their substrates There is enormous diversity in substrate ubiquitination and its regulation, as the targets of RING-type E3s are incredibly varied. RING-type E3s are implicated as tumor suppressors, oncogenes, and mediators of endocytosis, and play critical roles in complex mult
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br Materials and methods br Acknowledgments This research
2020-07-10
Materials and methods Acknowledgments This research was supported by funding from University of California Irvine to H.U.B. Introduction Oral squamous cell carcinoma (OSCC) is the fourth major cause of mortality among men in Taiwan and its incidence rates continue to rise annually. OSCC is
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In this review we first introduce
2020-07-10
In this review, we first introduce the in vivo metabolism profile of VD3, and the mediation of Cyp3a gene transcription by PXR and CAR in humans, mice and rats. We then focus on the species-specific VDR-dependent regulation of human (CYP3A4, CYP3A5 and CYP3A7), mouse (mainly CYP3A11 and CYP3A13), an
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Alvocidib flavopiridol is a piperidine chromenone http www a
2020-07-10
Alvocidib (flavopiridol) is a piperidine-chromenone derivative (Fig. 6D) that is not FDA approved, but is in clinical trials for breast, endometrial, and several other cancers and hematological malignancies (Table 4) [[100], [101], [102], [103], [104]]. This drug targets CDK9 (IC50 = 3.2 nM) and CDK
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Sixty eight male Sprague Dawley rats were acquired from the
2020-07-10
Sixty-eight male Sprague–Dawley rats were acquired from the University of South Dakota Laboratory Animal Services (Vermillion, SD, USA) and housed in pairs at 22°C (60% relative humidity) on reverse 12h light/dark PRIMA-1 (dark cycle started at 10:00a.m.) with food and water freely accessible. The p
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More recently evidence suggests that dysregulation of CRF si
2020-07-10
More recently, evidence suggests that dysregulation of CRF signaling may also be implicated in panic disorder. For instance, polymorphisms in the CRF1, but not CRF2, gene have been associated with susceptibility to panic disorder in German and Japanese population samples (Ishitobi et al., 2012, Keck
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Stressful life events are modulators of mood and
2020-07-10
Stressful life events are modulators of mood and can trigger a variety of destructive behavior, including drug abuse and relapse in addicts (Association, 2013; Chen et al., 2012; Sinha, 2009). Likewise, drug-associated stimuli evoke a negative affective state in abstinent drug users. Compelling evid
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Completion of h of education was
2020-07-10
Completion of 150 h of education was significant in virtually all prior studies of the 150-h requirement (Allen and Woodland, 2006, Boone et al., 2006 and others). While the 150-h requirement applies to licensure, students are often permitted (as in California) to sit for the CPA exam with fewer tot
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Introduction The inflammation process involves sequential
2020-07-10
Introduction The inflammation process involves sequential activation of signaling molecules, pro-inflammatory mediators, such as prostaglandins, leukotrienes, and oxygen free radicals [1]. Two cyclooxygenases Adenosine Kinase Inhibitor hydrate were responsible for activation of the production of pr
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br Results with scrubbing process Based on the
2020-07-10
Results with scrubbing process Based on KU-55933 discussion of Section 4.4 and area availability results of the previous section, scrubbing process, at the pixel processing rate, was included to mitigate error accumulation on the arrays and on the line-buffer. Eight sequential signals, plus the r
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Phytophthora capsici is a phytopathogenic
2020-07-10
Phytophthora capsici is a phytopathogenic oomycete, a lineage of eukaryotic microorganisms in the kingdom Stramenopila, which causes devastating diseases on many economically important vegetables [15]. Hyps are present in the Phytophthora cell wall proteins [16] and phytotoxic elicitor proteins [17]
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Our previous high throughput screening HTS campaign using
2020-07-10
Our previous high-throughput screening (HTS) campaign using automated, robust, and sensitive fluorescence based Schisandrol B assay [10], [11] led to the identification of several EPAC specific inhibitors (ESIs), and was subsequently followed by extensive hit-to-lead optimizations [20], [21], [22],
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