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In this study we have developed and
2020-12-30
In this study we have developed and investigated three NADPH-regenerating fusion partners with two different enzyme systems: a BVMO and an ADH. With the exception of one fusion construct (StGDH with LbADH), all fusion Bisindolylmaleimide VIII acetate resulted in good soluble expression as well as f
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br Introduction Sphingolipids are ubiquitous membrane compon
2020-12-30
Introduction Sphingolipids are ubiquitous membrane components of all eukaryotic cells belonging to a group of complex lipids. The basic structure of sphingolipids is composed of a sphingoid long chain base (LCB) linked to a fatty Hydrocortisone via an amide bond to form a ceramide [1]. In animal
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The most important finding in the present
2020-12-30
The most important finding in the present study is that the EKR1/2-Egr-1 signaling pathway might be involve in the mechanisms underlying CysLT2 receptor-mediated IL-8 production. The signaling profile can be described by the following sequential processes: the agonists (LTC4 and LTD4) activates CysL
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br P Y receptor structure br Pharmacology Several
2020-12-30
P2Y receptor structure Pharmacology Several subtype selective compounds have been developed in recent years (Jacobson and Müller, 2016; Rafehi and Müller, 2018). These compounds are helpful tools for analyzing the roles of P2Y receptor subtypes in physiology and pathophysiology. The present ar
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Many studies have shown that
2020-12-30
Many studies have shown that curcumin delays the progression of atherosclerosis in different atherosclerotic animal models [18], [19], [20], [37] and the risk of atherosclerosis in human studies [15], [38], [39]. Curcumin also has many properties that contribute to combat atherosclerosis, such as an
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br Discussion Nowadays data of
2020-12-30
Discussion Nowadays, data of uncommon EGFR mutations are limited, considering that patients carrying these rare alterations are usually excluded from clinical trials. Available survival data of activity of EGFR TKIs on this class of mutations, coming from a small number of usually retrospective s
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The lack of robust immunocompetent animal models permissive
2020-12-30
The lack of robust immunocompetent animal models permissive for HCV makes it hard to assess if the quantity and quality of vaccine-induced immunity is sufficient to confer protection. Thus, it is difficult to predict to what extent antibody responses induced by current vaccination approaches, includ
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At this stage it is
2020-12-30
At this stage it is still difficult to assign specific domains to some of the regions observed in these structures, although some attempts have already been made (Brewerton et al., 2004). Clearly, higher resolution data is needed. In the future, even if an atomic structure of DNA-PKcs is determined,
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Dexamethasone DEX a potent synthetic glucocorticoid drug is
2020-12-29
Dexamethasone (DEX), a potent synthetic glucocorticoid drug, is effective for treatment of a range of inflammatory and autoimmune conditions as well as the reduction of side effects associated with chemotherapy. On the Czech Republic pharmaceutical market, DEX is incorporated into eighteen drugs use
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The proposed FDIR technique is presented
2020-12-29
The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the kinesin inhibitor environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estimat
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Organ fibrosis is thought to be initiated
2020-12-29
Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial Alexidine dihydrochloride induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells act
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br Discussion Variable estradiol effects on
2020-12-29
Discussion Variable estradiol effects on cell proliferation have been reported according to animal species, tissues, and type of estrogen receptor [16,21,22,[29], [30], [31]]. In the kidney, 17βE was found to increase [3H]-thymidine incorporation in primary rabbit kidney proximal tubule HBTU [30]
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Damage of PE HD due to both mechanisms is usually
2020-12-29
Damage of PE-HD due to both mechanisms is usually considered to emerge from a local stress concentration in the material, leading to the initiation of a crack, which subsequently propagates further through the material, and finally leads to macroscopic failure. In this process, crack growth occurs o
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Early VL diagnosis makes it possible to formulate a quicker
2020-12-29
Early VL diagnosis makes it possible to formulate a quicker and more effective treatment against the disease, which could increase the possibility of a cure for the patients, as well as reduce the toxicity of the drugs (Coelho et al., 2009); however, conventional and molecular parasitological method
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br Conclusions br Acknowledgements Implantable Microsystems
2020-12-29
Conclusions Acknowledgements Implantable Microsystems for Personalised Anti-Cancer Therapy is a EPSRC (Engineering and Physical Sciences Research Council, UK) funded grant (Ref. EP/K034510/1) Introduction Flemingia philippinensis, belonging to the legume family, is a polyphenol rich plant
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