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Oral antipsychotics are substrates of CYP enzymes which are
2021-05-18
Oral antipsychotics are substrates of CYP450 enzymes, which are crucial to their metabolism and elimination (Fig. 1). The efficacy and toxicity of antipsychotic agents is affected by factors that induce or inhibit CYP450 expression and function, such as drug–drug interactions. Additionally, the mult
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To elucidate the potential mechanism underlying osteosarcoma
2021-05-18
To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine Glucagon (19-29), human synthesis and apoptosis in human osteosarcoma cells after palbociclib treatment. The results showed that osteosarcoma cells wer
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br Materials and methods br Results and discussion
2021-05-18
Materials and methods Results and discussion Conclusions Conflict of interest Acknowledgments This work was financially supported by the National Natural Science Foundation of China (31302162, 31171762), National High Technology Research and Development Program of China (863 Program,
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Missed Opportunities Targeting a specific cell type rather t
2021-05-18
Targeting a specific cell type, rather than the broad cytotoxicity exhibited by some of the pharmacological agents currently used to treat lupus, may improve efficacy and decrease off target toxicity. Thus, evidence that macrophages and microglia are important to the pathogenesis of LN and NPSLE, re
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In contrast to PEGylated proteins which tend
2021-05-18
In contrast to PEGylated proteins which tend to have reduced Ellagic acid in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the field of
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Cefotaxime sodium salt Placental insufficiency is regarded a
2021-05-18
Placental insufficiency is regarded as the main etiology for FGR. Placental development is highly unique in eutherians and is regulated by numerous factors. For example, the novel retrotransposon-derived gene retrotransposon-like 1 (RTL1) was recently shown to play a key role in placental developmen
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br Theory br Method To test our hypotheses as shown
2021-05-18
Theory Method To test our hypotheses as shown in Fig. 1, we conducted a survey at an international media company (hereafter referred to as ‘MediaCo’) headquartered in the UK. Its 5500 employees are dispersed throughout the world, partly due to massive acquisitions within the past decade. In e
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Meanwhile high levels of extraversion have been associated w
2021-05-18
Meanwhile, high levels of extraversion have been associated with weaker conditioning and faster ion channels learning (Eysenck, 1970). Similar to neuroticism/anxiety, the role of extraversion for fear conditioning and extinction has found only limited empirical support (Rauch et al., 2005) with sev
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Sampling sediments is usually performed with grab corers The
2021-05-18
Sampling sediments is usually performed with grab corers [16], [29]. The digested sludge analyzed by Ternes et al. [16] was taken directly from the digester and the activated sludge was obtained by Z-IETD-FMK of the slurry of STPs [16]. Collected samples are transported under cooled conditions (+4
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br Methods br Results and discussion br Conclusions br
2021-05-18
Methods Results and discussion Conclusions Conflict of interest Acknowledgment The research is supported by the National Natural Science Foundation of China (Grant No. U1603285). Overview of the MAPK pathway The mitogen-activated protein kinases (MAPK) pathway, often known as a ca
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In mammals ribonucleotide reductase RNR is a unique enzyme
2021-05-18
In mammals, ribonucleotide reductase (RNR) is a unique enzyme that catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleoside triphosphates (dNTPs).7, 8 Mammalian RNR consists of two homodimer subunits: the large catalytic dimer RRM1 and the small regulatory dimer RRM2 or RRM2B. An
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Prostanoids typically act in an autocrine and paracrine fash
2021-05-18
Prostanoids typically act in an autocrine and paracrine fashion by binding to specific receptors in target Cy7 carboxylic acid (non-sulfonated) receptor and there is evidence that both PGE2 and prostacyclin may be required for the optimal activation of angiogenesis (Hata and Breyer, 2004). PGE2 and
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Our present results support a major role of EP receptors
2021-05-18
Our present results support a major role of EP1 receptors in peripheral heat sensitization and a smaller contribution to central heat sensitization but no contribution to mechanical sensitization. While the contribution of peripheral EP1 receptors to heat hyperalgesia is in good agreement with the a
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br O GlcNAcase Human OGA
2021-05-18
O-GlcNAcase Human OGA is a multidomain protein with an N-terminal domain similar to glycoside hydrolase family 84 (GH84) enzymes, a stalk domain, a C-terminal pseudo histone acetyltransferase (HAT) domain, and several low-complexity regions (Figure 1f) [43]. A splice variant that lacks the HAT do
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Endothelin appears to have direct effects on
2021-05-18
Endothelin 1 appears to have direct effects on neoplastic ARRY-142886 by inducing cellular proliferation, angiogenesis, migration, invasion, and inhibition of apoptosis [10]. Endothelin 1 mediates mitogenic effects in some epithelial tumors such as colorectal, ovarian, and prostate cancers [11], [1
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