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br Materials and methods br Results
2021-06-25
Materials and methods Results and discussion Conclusions Acknowledgments This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (No. 2011-0030635) and the MarineBio Research Program (NRF-C1ABA001-2011-0018561). The Fonta
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br Introduction Phoenixin PNX is a recently discovered pepti
2021-06-25
Introduction Phoenixin (PNX) is a recently discovered peptide produced mainly in hypothalamus by proteolytic cleavage of a small integral membrane protein 20 (Smim20) [1]. The most important endogenous active isoforms of PNX are amided peptides, composed of 14 and 20 monoamine oxidase inhibitor
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Some natural products such as curcumin resveratrol
2021-06-25
Some natural products, such as curcumin, resveratrol, and sulforaphane, are known to activate Nrf2 in both in vivo and in vitro experimental models where Nrf2-mediated gene AGK 2 plays a crucial protective role [8]. Under basal conditions, Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) r
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br Materials and methods br Results br Discussion
2021-06-25
Materials and methods Results Discussion Anti-EGFR therapy for epithelial carcinomas has important clinical significance, but widespread intrinsic or acquired resistance seriously affects efficacy. Mutation and heterodimerization of EGFR are the two main causes of resistance to anti-EGFR th
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In another study Nutlin a mediated p activation induced stro
2021-06-25
In another study, Nutlin-3a-mediated p53 activation induced strong negative impact on NF-κB signaling in LPS-stimulated neutrophils and macrophages [34]. Nutlin-3a limited cellular immune response to LPS, partly by attenuating DNA binding activity of NF-κB and impairing transcription of its target c
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A role for the E E interface
2021-06-25
A role for the E2–E3 interface in governing mono- versus polyubiquitination is not mutually exclusive with that of the E2 backside, which has previously been shown to mediate polyubiquitination through its ability to bind to Ub [21], [25], [33]. Brzovic and colleagues first demonstrated the importan
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Given the structural similarity of
2021-06-25
Given the structural similarity of BMAA to other amino acids, our hypothesis was that N-nitrosation of BMAA might result in a toxic alkylating agent, providing a previously unrecognised mechanism for BMAA action. Materials and methods Results and discussion We first examined whether chemical
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br Introduction Diacylglycerol kinase DGK is a lipid metabol
2021-06-25
Introduction Diacylglycerol kinase (DGK) is a lipid-metabolizing enzyme that phosphorylates diacylglycerol (DG) to produce phosphatidic NS 11021 (PA) [[1], [2], [3], [4]]. DG and PA act as lipid second messengers in a wide variety of biological processes. Ten DGK isozymes (α, β, γ, δ, η, κ, ε, ζ,
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Dabrafenib br Subjects and methods br Results
2021-06-24
Subjects and methods Results Discussion In the present study, we found significantly increased CSF levels of IL-4, IL-5, IL-9, IL-10, TNF-α, CXCL8/IL-8, and VEGF-A together with significantly higher detection rates of IL-6, GM-CSF, PDGF-BB and IL-1ra in IHP patients compared with OND patien
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br Materials and methods br Results br Discussion
2021-06-24
Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated Pramipexole guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimulated by both LTC4 and LT
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br Thermodynamic modeling br Selection
2021-06-24
Thermodynamic modeling Selection of data The solutes were selected based on the set of data needed to evaluate the CPA-EoS for prediction of their solubility in CO2 + cosolvent, as shown in Fig. 1. Critical temperatures, melting temperatures and enthalpies of fusion of the solutes are required
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Since inception of the accelerated program in California has
2021-06-24
Since inception of the accelerated program in 2000, California has varied the requirements for CPA licensure. Prior to 2002, licensure was available with a bachelor’s degree in any subject, 24 semester hours (36 quarter units) of accounting, 24 semester hours (36 quarter units) of general business,
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Magnetic interactions between metal ions are usually
2021-06-24
Magnetic interactions between metal ions are usually described by superexchange via intermediate ligands. Although the general principles of the superexchange mechanism are essentially the same for d and f ions, calculations of exchange parameters for lanthanides are more difficult than for transiti
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Due to the results of the experiment we decided to
2021-06-24
Due to the results of the experiment we decided to deploy our cloud service infrastructure with two platform-independent servers instead of one or three. This decision was based on two factors: (a) the use of more than one server is useful to avoid a bottleneck in the system, and (b) using more than
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Inopportunely normal aging brings about
2021-06-24
Inopportunely, normal aging brings about decreases in frontal D1 receptor densities and a gradual decline in postsynaptic markers of dopamine in striatal, neocortical, and limbic areas of the BMS-509744 (Bäckman et al., 2006, de Keyser et al., 1990, Karrer et al., 2017, Suhara et al., 1991, Wang et
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