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Measured physicochemical water parameters including
2021-12-20
Measured physicochemical water parameters including conductivity, suspended solids and nutrient load along the studied sites (Table 1) were high compared to levels usually found in undisturbed rivers within Europe (Chapman and Kimstach, 1996). In particular conductivity, suspended solids and phospha
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br Biochemical properties and post translational modificatio
2021-12-20
Biochemical properties and post-translational modification of GCAPs GCAPs are hydrophobic proteins that are likely permanently bound to their GC target under physiological conditions [5]. They interact with the photoreceptor GCs through the intracellular domains (reviewed in [17]). GCAP1 has been
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br Acknowledgments This work was
2021-12-20
Acknowledgments This work was supported by the National Institutes of Health (R01 A1084898) to M.V. Williams and M.E. Ariza. Introduction Female pattern hair loss (FPHL) has emerged as the preferred term for androgenetic alopecia (AGA) in women due to the uncertain relationship between androg
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T lymphocytes play an important role
2021-12-20
T lymphocytes play an important role in cellular and humoral immunity and immune responses (Shin and Iwasaki, 2013; Schenkel and Masopust, 2014). T a23187 receptor mature after complex selection and differentiation in the thymus. They can express various membrane proteins, such as CD3, CD4, and CD8
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The amino hydroxy methyl isoxazolepropionic acid
2021-12-20
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic DCA (AMPA) receptors are related ionotropic glutamate receptors (iGluRs) that mediate fast excitatory neurotransmission, and are also typically heteromeric ion channels, composed of GluA2 subunits in conjugation with GluA1, GluA3, or GluA4 subunits
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To maintain low Glu concentrations in the synaptic cleft
2021-12-20
To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino AP 18 mg is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and in
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The ER EK polymorphism is located
2021-12-20
The ER22/23EK polymorphism is located in the transactivation domain of the GR gene. A single nucleotide polymorphisms (SNPs) has been identified in both of the two adjacent codons (22 and 23). These SNPs are fully linked and are associated with relative GC resistance[32], [44]. Although no associati
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Murine models of sickle disease have been
2021-12-20
Murine models of sickle disease have been valuable tools in the study of human SCD pathogenesis [15], [16], and will continue to be central to development of novel approaches to disease treatment. The SAD mouse model of sickle disease is particularly remarkable for its erythrocyte dehydration phenot
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DNAzymes a series of nucleotide sequences with
2021-12-20
DNAzymes, a series of nucleotide sequences with specific catalytic activity, have been reported frequently applied in detection assays for such as ions and amino acids, due to the advantage in stability, high cost-effectiveness and modification convenience, by comparison with protein enzymes. The DN
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It is noted that knee swelling was
2021-12-20
It is noted that knee swelling was milder and the intensity of IL-4 staining (MFI) in the vehicle-treated group was lower in the second (Fig. 7a and d) than the first (Figs. 1a and 3f) AIA experiment. The variation in joint swelling between the two studies is most likely due to the models being perf
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In the FARM motifs of GGPPSs
2021-12-20
In the FARM motifs of GGPPSs, hydrophobic fumonisin are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP synthase (GGPPS
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EZH interaction with HADC and
2021-12-20
EZH2 interaction with HADC1 and HDAC2 through the EED subunit is known to recruit histone deacetylases [113,114]. Given that PRC2-mediated repression of transcription may be partly dependent on the function of HDACs in specific cell contexts [115], the leukemia cell treatment with hydroxamic Heparin
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The above mentioned studies are especially important since t
2021-12-20
The above-mentioned studies are especially important since the structural alterations of the peritoneum during peritoneal dialysis are very similar to vascular and tissue alteration seen in diabetes. The tissue alterations during long-term peritoneal dialysis include a thickening and replication of
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br Experimental br Acknowledgments br
2021-12-20
Experimental Acknowledgments Human immunodeficiency virus-1 (HIV-1) is the causative agent of acquired immunodeficiency syndrome (AIDS), and without treatment results in a debilitating disease that cripples the immune system of the patient, increasing susceptibility to opportunistic diseases
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CHIR-98014 Introduction The Antiretroviral Therapy ART
2021-12-20
Introduction The Antiretroviral Therapy (ART), in the last decade, has been providing a better treatment for the Human Immunodeficiency Virus 1 (HIV) infection, by reducing its viral load to undetectable levels and recovering the immune system. In fact, according to the last data from UNAIDS the m
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