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br Novel mechanisms of fipronil resistance in planthoppers
2022-07-14
Novel mechanisms of fipronil resistance in planthoppers Conclusion Conflict of interest Introduction Methamphetamine, a widely abused drug, is mainly used as a psychostimulant although it is occasionally used at low doses for medical purposes, such as in attention deficit or hyperactivit
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The VirScan assay has several advantages over
2022-07-14
The VirScan assay has several advantages over alternative multiplex serological assays for peptide discovery. These advantages include quantitative assessment of antibody binding to peptides that span all open reading frames in the HIV genome, including both structural and regulatory proteins; repre
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The mechanism study demonstrated that BDNF is
2022-07-14
The mechanism study demonstrated that BDNF is one of the fundamental mechanisms underlying JMJD2A effects during neuropathic pain. BDNF is a neurotrophin with essential functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels un
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The H R antagonist cimetidine Tagamet became the
2022-07-14
The H2R antagonist cimetidine (Tagamet™) became the first billion-dollar drug in the 1980s for the treatment of peptic ulcer disease. Other H2R antagonists include ranitidine, famotidine, nizatidine, and zolantidine, the latter showing good BBB penetration with a steady-state brain/blood ratio of 1.
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Concanamycin A Several mechanisms have been suggested to
2022-07-14
Several mechanisms have been suggested to underline the release of signalling molecules from astrocytes: reverse operation of glutamate transporters, volume-regulated anion channels, gap-junctional hemi channels, diffusional release through purinergic receptors and Ca2+-dependent exocytosis [2], [15
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br Prostaglandins meet Hippo The prostaglandins lie at
2022-07-14
Prostaglandins meet Hippo The prostaglandins lie at the crossroads between inflammation, regeneration and tumorigenesis (Figure 3). Prostaglandins are synthesized from archidonic Rapalink-1 by Cox1 and Cox2 enzymes [40, 41] and in the gut, prostaglandin E2 (PGE2) protects against DSS-induced col
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br Authors contribution br Funding sources This study
2022-07-13
Authors' contribution Funding sources This study was supported by CDC intramural funding. Publication costs are funded by an internal program of CDC. MAT was supported by funds from the Association of Public Health Laboratories and CDC (APHL–CDC) Bioinformatics Fellowship Program. Competing
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It would also be interesting
2022-07-13
It would also be interesting to understand the potential connection between asymmetric histone inheritance and another phenomenon reported by several investigators: selective DNA strand segregation (reviewed by Evano and Tajbakhsh, 2013, Rando, 2007, Tajbakhsh and Gonzalez, 2009). Recent development
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Distribution of Iodine labeled ANP
2022-07-13
Distribution of 125Iodine-labeled-ANP (125I-ANP) radioactivity on the cell surface, in the intracellular compartments, and in culture medium established a dynamic equilibrium of receptor-mediated 125I-ANP uptake, degradation, and release outside of Cy3-dCTP (Fig. 2). A major proportion of internali
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br Materials and methods br Results As expected
2022-07-13
Materials and methods Results As expected, due to matching by age, the mean ages were similar for the two groups of children when stratified by ASD status; children with an ASD had a mean age of 67.0 months, while the mean age for children in the TD control group was 68.0 months. Nearly all of
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Abnormal expression and higher activity of GLO
2022-07-13
Abnormal expression and higher activity of GLO I have been detected more in various tumor ppar pathway than in normal cell samples., , , , , , , Among cancer cell lines, lung carcinoma cells frequently showed higher GLO1 activity. Human NSCLC cell line NCI-H522 cells possess high activity and expr
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Also considered very rare is
2022-07-13
Also considered very rare is progressive encephalomyelitis with rigidity and myoclonus (PERM); sometimes called Stiff Person Syndrome Plus (SPS Plus) and with antibodies to glutamic ndga australia decarboxylase (GAD). However, PERM is now increasingly found with glycine receptor antibodies (GlyR-Ab
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br Evasion strategies for enhanced therapeutic outcomes In
2022-07-13
Evasion strategies for enhanced therapeutic outcomes In order to increase AED penetration into the CNS, several strategies have been developed over the years to overcome the activity of efflux transporters, by inhibiting their function or by regulating their expression. Due to the high relevance
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Thus this work aims to evaluate
2022-07-12
Thus, this work aims to evaluate the effect of tannic protoporphyrin ix on β-galactosidase activity, by observing the variations in the molecular interaction kinetic parameters ( and ). Besides, these data were correlated with the modifications that the tannin caused to the enzyme’s secondary struc
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We found that silymarin induced more improvement
2022-07-12
We found that silymarin induced more improvement of renal functions compared to Rvs. Our results were in agreement with previous studies. The effect of silymarin has been tested in alloxan-induced diabetes mellitus models in rats. Alloxan produces reactive oxygen species which injure renal tissue. S
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