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br ABCA mRNA expression is elevated in Niemann Pick type
2024-02-21
ABCA2 mRNA expression is elevated in Niemann-Pick type C and familial hypercholesterolemia fibroblasts Niemann-Pick Type C disease is a neurological disorder of adolescents due to autosomal-recessive mutations in either one or both Niemann-Pick-2 (NPC2) and NPC1 genes, which, like ABCA2, are loca
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We further analyzed selected hit compounds
2024-02-21
We further analyzed selected hit compounds for their ability to inhibit human AdK in intact cells. Human 1321N1 astrocytoma CNQX were utilized which were found to express AdK. The whole cell assay was performed using a 96-well format. The standard AdK inhibitor 5-iodotubercidin was employed as a po
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Until now there are no report regarding the
2024-02-21
Until now, there are no report regarding the relationship of CD21 and MG. In the present study, we aimed to characterize the AchR specified Concanamycin A and investigated the role of CD21 in immunopathogenesis of MG. We utilized the Allophycocyanin (APC)-conjugated AchR to measure the frequencies o
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e3 ligases NSAIDs induce gastrointestinal toxicity and evoke
2024-02-21
NSAIDs induce gastrointestinal toxicity and evoke e3 ligases by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001; Koeberle and Werz, 2015;
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It was previously demonstrated that dissociation of the
2024-02-21
It was previously demonstrated that dissociation of the V-ATPase in response to glucose depletion in yeast requires an intact microtubular network [28] and a catalytically active enzyme [29]. Interestingly, mutations in the non-homologous region of the catalytic subunit A are able to block dissociat
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A unique finding in this study
2024-02-21
A unique finding in this study is that 12/15-LO influences CREB phosphorylation in the murine brain. While previous reports have found that knockout of 5-lipoxygenase, a related enzyme that also uses arachidonic annexin v for substrate, can regulate CREB phosphoryation in the context of Alzheimer's
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br Acknowledgements We would like to thank Dr
2024-02-21
Acknowledgements We would like to thank Dr. Thomas Blanpied, Sai Sachin Divakaruni, Dr. Helmut Kessels, Feline Lindhout, Dieudonnée van de Willige, and all members of the MacGillavry lab for discussions and critical reading of the manuscript. This work was supported by NWO (ALW-VENI 863.13.020, A
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br Acknowledgments br Introduction Cancer is a deadly diseas
2024-02-21
Acknowledgments Introduction Cancer is a deadly disease of uncontrolled cell division and has the potential to invade or spread to other parts of the body and affects normal functioning of the vital organs. Nowadays cancer is considered as leading cause of human death in all over the world and
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br The role of apelin in hypertension
2024-02-21
The role of apelin in hypertension diseases The role of apelin and its receptor APJ in cardiovascular diseases has been described in numerous studies (Table 2) [36,37]. It has been revealed that exogenous apelin may lower blood pressure. Tatemoto et al. [6] have discovered that different forms of
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AGN 194310 The studies have described that Candida non albic
2024-02-21
The studies have described that Candida non-albicans are considered as remarkable pathogenic agents of OPC, and among them, C. tropicalis and C. glabrata are known as major strains that may replace C. albicans as the greatest causing agent of this infection [20], [21]. It has been shown that Candida
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Ala a branched chain amino acid has been reported to
2024-02-20
Ala, a branched chain amino acid, has been reported to play a functional role in intracellular pH regulation, and it typically accumulates in response to various stresses (Limami et al., 2008, Rocha et al., 2010). Our data demonstrated that increasing Cd concentrations at lower Cd doses resulted in
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Liver plays a pivotal role in
2024-02-20
Liver plays a pivotal role in metabolism of xenobiotic compounds, such as environmental contaminants and drugs. Some of these compounds generate hepatic damage and impair its function. It was well-known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could induce pathological changes in mouse and ra
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Further examination of these vmat IR cells
2024-02-20
Further examination of these vmat-IR cells shows that they are also positive for vimentin (vim-IR) (Fig. 3A). However, within any one cell there may be a region of weaker vmat-IR, suggesting sub-cellular localization. As also shown in Fig. 3B and C not all vim-IR cells are vmat-IR suggesting that th
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Normally the activity of the lyase increases with
2024-02-20
Normally, the activity of the 17,20-lyase increases with the onset of adrenarche [7], [8], [15]. Adrenarche has previously been perceived as a relatively sudden event, occurring physiologically between 6 and 8years of age. However, results from our laboratory clearly indicated that adrenarche is a c
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Aurora A and B are required for the control of
2024-02-20
Aurora A and B are required for the control of mitosis whereas Aurora C is mainly invoved in meiosis (Goldenson and Crispino, 2015). Interestingly, Aurora B is partnered with inner centromere protein (INCENP), survivin and Borealin to form a chromosomal passenger complex (CPC) that is critical for t
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